Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.10 [-0.29, 0.50]
2 studies · 43 participants
GRADE not reported
MD -1.00 [-1.78, -0.22]
1 study · 22 participants
Very low
MD -0.43 [-0.88, 0.01]
3 studies · 65 participants
GRADE not reported
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.38 [0.00, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.00 [0.30, 1.70]
1 study · 27 participants
Very low
MD -0.16 [-0.56, 0.24]
2 studies · 49 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD -0.05 [-0.22, 0.12]
1 study · 22 participants
GRADE not reported
Included studies have not reported this outcome
Studies not reported
No studies found
MD -0.07 [-0.29, 0.15]
1 study · 22 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Antimicrobial resistance · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.01 [-0.21, 0.19]
1 study · 21 participants
GRADE not reported
Included studies have not reported this outcome
Studies not reported
No studies found
MD -0.09 [-0.29, 0.11]
1 study · 21 participants
GRADE not reported
Antimicrobial resistance · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).
1 finding from 1 review
Adverse events · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
1 finding from 1 review
Probing pocket depth (PPD/PD) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).
1 finding from 1 review