Intravitreal dexamethasone implant 0.7 mg vs sham
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · macular edema in diabetes
1 finding from 1 review
- no estimate extracted1 study · 701 participantsModerate
Findings
What do systematic reviews say?
12 questions · 12 findings · 1 reviews · Eyes and Vision · Headline outcomes only
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 8.3%Low 3 · 25%Moderate 8 · 66.7%High 0 · 0%
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Cataract progression · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher cataract progression ‐ 12 to 24 months compared with intravitreal antiVEGF (moderate certainty).
1 finding from 1 review
- RR 4.23 [2.36, 7.59]Studies not reportedModerate
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher use of IOP‐lowering medications ‐ 24 months compared with intravitreal antiVEGF (moderate certainty).
1 finding from 1 review
- RR 4.76 [2.84, 7.99]Studies not reportedModerate
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Surgery for glaucoma ‐ 24 months · macular edema in diabetes
It is very uncertain whether intravitreal dexamethasone implant 0.7 mg changes surgery for glaucoma ‐ 24 months compared with intravitreal antiVEGF (very low certainty).
1 finding from 1 review
- RR 3.02 [0.12, 73.56]Studies not reportedVery low
Intravitreal dexamethasone implant 0.7 mg vs sham
Gain 3+ lines of visual acuity at 1 year · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg showed no clear difference in gain of three or more lines visual acuity ‐ 12 months compared with sham (moderate certainty).
1 finding from 1 review
- RR 1.39 [0.91, 2.12]1 study · 701 participantsModerate
Intravitreal dexamethasone implant 0.7 mg vs sham
Change in retinal thickness (micron) (negative is better) · macular edema in diabetes
1 finding from 1 review
- no estimate extracted1 study · 701 participantsModerate
Intravitreal dexamethasone implant 0.7 mg vs sham
Cataract progression · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher cataract progression ‐ 36 months compared with sham (moderate certainty).
1 finding from 1 review
- RR 3.89 [2.75, 5.5]1 study · 697 participantsModerate
Intravitreal dexamethasone implant 0.7 mg vs sham
Use of IOP‐lowering medications · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher use of IOP‐lowering medications ‐ 36 months compared with sham (moderate certainty).
1 finding from 1 review
- RR 4.54 [3.19, 6.46]1 study · 697 participantsModerate
Intravitreal dexamethasone implant 0.7 mg vs sham
Surgery for glaucoma · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg showed no clear difference in surgery for glaucoma ‐ 36 months compared with sham (low certainty).
1 finding from 1 review
- RR 5.04 [0.59, 42.95]1 study · 697 participantsLow
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · macular edema in diabetes
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Gain 3+ lines of visual acuity at 1 year · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg may leads to lower gain of three or more lines visual acuity ‐ 12 months compared with intravitreal antiVEGF (low certainty).
1 finding from 1 review
- RR 0.99Studies not reportedLow
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Change in retinal thickness (micron) ‐ 12 months (negative is better) · macular edema in diabetes
1 finding from 1 review
- no estimate extractedStudies not reportedLow