Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 2 reviews

No studies found 6 · 27.3%GRADE not reported 0 · 0%Very low 7 · 31.8%Low 4 · 18.2%Moderate 5 · 22.7%High 0 · 0%

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Drug‐related AE: serum creatinine increased (≥ 33%) above baseline in 2 consecutive occasions · people with transfusion‐dependent thalassemia

It is very uncertain whether deferasirox and deferiprone changes drug‐related AE: serum creatinine increased (≥ 33%) above baseline… compared with deferiprone and deferoxamine (very low certainty).

1 finding from 1 review

Deferasirox vs deferoxamine

End‐organ damage (incidence of diabetes) · patients with managing transfusional iron overload in people with sickle cell disease

It is very uncertain whether deferasirox changes end‐organ damage (incidence of diabetes) compared with deferoxamine (very low certainty).

1 finding from 1 review