Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 5 reviews · Orthodontics

No studies found 0 · 0%GRADE not reported 7 · 46.7%Very low 5 · 33.3%Low 2 · 13.3%Moderate 1 · 6.7%High 0 · 0%

Extra-oral pulp extirpation at day 0 vs Intra-oral pulp extirpation at day 7

Radiographic resorption (proxy measure for periodontal healing) at 12 months · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether extra-oral pulp extirpation at day 0 changes radiographic resorption (proxy measure for periodontal healing) at… compared with intra-oral pulp extirpation at day 7 (very low certainty).

1 finding from 1 review

Ledermix root canal medicament (day 0 to 10) vs Ultracal root canal medicament (day 7 to 10)

Aesthetics (discolouration) at 12 months (patient level) · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether ledermix root canal medicament (day 0 to 10) changes aesthetics (discolouration) at 12 months (patient level) compared with ultracal root canal medicament (day 7 to 10) (very low certainty).

1 finding from 1 review

Ledermix root canal medicament (day 0 to 10) vs Ultracal root canal medicament (day 7 to 10)

Tooth survival · People with avulsed and replanted permanent (front) teeth
1 finding from 1 review

Ledermix root canal medicament (day 0 to 10) vs Ultracal root canal medicament (day 7 to 10)

Periodontal healing at 12 months · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether ledermix root canal medicament (day 0 to 10) changes periodontal healing at 12 months (tooth level) compared with ultracal root canal medicament (day 7 to 10) (very low certainty).

1 finding from 1 review

Superelastic NiTi arch wire vs Conventional (stabilised) NiTi arch wire

Pain day 1 · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Superelastic NiTi arch wire showed no clear difference in pain day 1 compared with conventional (stabilised) NiTi arch wire (low certainty).

1 finding from 1 review

Light-emitting diode (LED) photobiomodulation vs Conventional orthodontic appliance treatment

Rate of orthodontic tooth movement during space closure stage (maxillary canine distalisation), mm/day · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

It is very uncertain whether light-emitting diode (LED) photobiomodulation changes rate of orthodontic tooth movement during space closure stage… compared with conventional orthodontic appliance treatment (very low certainty).

1 finding from 1 review

Active self-ligating brackets vs Passive self-ligating brackets

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Active self-ligating brackets showed no clear difference in time to alignment (days) compared with passive self-ligating brackets; GRADE not reported.

1 finding from 1 review

Self-ligating brackets vs Conventional brackets

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Self-ligating brackets showed no clear difference in time to alignment (days) compared with conventional brackets; GRADE not reported.

1 finding from 1 review

Vibrational appliance with fixed appliances vs Fixed appliances

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Vibrational appliance with fixed appliances showed no clear difference in time to alignment (days) compared with fixed appliances only / no vibrational appliance (control); GRADE not reported.

1 finding from 1 review

Copper nickel-titanium archwire vs Nickel-titanium archwire

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Copper nickel-titanium archwire showed no clear difference in time to alignment (days) compared with nickel-titanium archwire; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Patient response: moderate or severe pain at 1 day postoperative · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in patient response: moderate or severe pain at 1 day postoperative compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review