What do systematic reviews say?

Daily conventionally fractionated radiotherapy vs supportive care

Daily conventionally fractionated radiotherapy probably leads to higher overall survival compared with no radiotherapy (supportive care alone) (moderate certainty).

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  HR 2.01 [1.58, 2.55]
  4 studies · 397 participants
  Moderate

Daily conventionally fractionated radiotherapy vs supportive care

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 289 participants
  GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 81 participants
  GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 81 participants
  GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

It is very uncertain whether hypofractionated radiotherapy changes overall survival compared with daily conventionally fractionated radiotherapy (very low certainty).

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  HR 0.95 [0.78, 1.17]
  5 studies · 943 participants
  Very low

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 848 participants
  GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 361 participants
  GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Hypofractionated radiotherapy showed no clear difference in overall survival for subgroup aged ≥ 60 years glioblastoma compared with daily conventionally fractionated radiotherapy (high certainty).

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  HR 1.16 [0.92, 1.46]
  2 studies · 293 participants
  High