Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

80 questions · 87 findings · 6 reviews · Skin · Headline outcomes only

No studies found 20 · 23%GRADE not reported 4 · 4.6%Very low 12 · 13.8%Low 33 · 37.9%Moderate 17 · 19.5%High 1 · 1.1%

Corticosteroids vs no corticosteroid use

Disease‐specific mortality ‐ SJS and TEN (time to · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

It is very uncertain whether corticosteroids changes disease‐specific mortality ‐ SJS and TEN (time to compared with no corticosteroids (very low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

Adverse effects leading to discontinuation of SJT/TEN therapy ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

The review found no eligible studies for this question.

1 finding from 1 review