Findings

What do systematic reviews say?

4 questions · 5 findings · 1 reviews · Acute Respiratory Infections · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 0 · 0%Moderate 3 · 60%High 0 · 0%

All‐cause mortality; · Ventilator‐associated pneumonia

Monotherapy showed no clear difference in all‐cause mortality; compared with combination therapy (moderate certainty).

1 finding from 1 review

Antibiotics for ventilator‐associated pneumonia 2016 · Cochrane Headline outcomes only
OR 0.97 [0.73, 1.3]
4 studies · 1163 participants
Moderate

Clinical cure · Ventilator‐associated pneumonia

It is very uncertain whether monotherapy changes clinical cure (ITT) compared with combination therapy (very low certainty).

2 findings from 1 review

Antibiotics for ventilator‐associated pneumonia 2016 · Cochrane Headline outcomes only
OR 0.88 [0.56, 1.36]
2 studies · 350 participants
Very low
Antibiotics for ventilator‐associated pneumonia 2016 · Cochrane Headline outcomes only
OR 0.97 [0.56, 1.68]
2 studies · 228 participants
Very low

Adverse events · Ventilator‐associated pneumonia

Monotherapy showed no clear difference in adverse events compared with combination therapy (moderate certainty).

1 finding from 1 review

Antibiotics for ventilator‐associated pneumonia 2016 · Cochrane Headline outcomes only
OR 0.93 [0.68, 1.26]
2 studies · 921 participants
Moderate

Duration of ICU stay · Ventilator‐associated pneumonia

1 finding from 1 review

Antibiotics for ventilator‐associated pneumonia 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 813 participants
Moderate