Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Stroke

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 100%High 0 · 0%

Death or dependency · people with acute stroke

Chlormethiazole showed no clear difference in death or dependency compared with placebo (moderate certainty).

1 finding from 1 review

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke 2018 · Cochrane Headline outcomes only
RR 1.03 [0.96, 1.11]
4 studies · 2909 participants
Moderate

Adverse events · people with acute stroke

Chlormethiazole probably leads to higher adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke 2018 · Cochrane Headline outcomes only
RR 4.56 [3.5, 5.95]
2 studies · 2527 participants
Moderate

Functional independence · people with acute stroke

Chlormethiazole showed no clear difference in functional independence compared with placebo (moderate certainty).

1 finding from 1 review

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke 2018 · Cochrane Headline outcomes only
RR 0.98 [0.92, 1.05]
4 studies · 2909 participants
Moderate

Other stroke scales · people with acute stroke

1 finding from 1 review

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1367 participants
Moderate