Findings

What do systematic reviews say?

5 questions · 6 findings · 2 reviews · Oral Health · All outcomes

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No studies found 0 · 0%GRADE not reported 5 · 83.3%Very low 1 · 16.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Summary of findings table ‐ Topical capsaicin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
4 weeks
Three participants from the topical capsaicin group withdrew from the study by Winocur et al 2000 due to the severity of the burning sensation and redness.
1 study · 30 participants
GRADE not reported

Summary of findings table ‐ Topical capsaicin vs placebo

Pain on daily activity (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in pain on daily activity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
4 weeks
MD -1.12 [-3.12, 0.88]
1 study · 30 participants
GRADE not reported

Summary of findings table ‐ Topical capsaicin vs placebo

Maximum pain while on medication (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in maximum pain while on medication (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
4 weeks
MD -0.91 [-2.89, 1.07]
1 study · 30 participants
GRADE not reported

Summary of findings table ‐ Topical capsaicin vs placebo

Present pain of TMD (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in present pain of TMD (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
4 weeks
MD -0.61 [-2.45, 1.23]
1 study · 30 participants
GRADE not reported

Topical treatments (capsaicin oral rinse) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

2 findings from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · capsaicin oral rinse
Capsaicin oral rinse (Marino 2010; Silvestre 2012) contributes to the topical treatments short-term symptom-relief comparison (insufficient/contradictory). Silvestre 2012 data not presented due to 23% first-phase…
1 study
GRADE not reported
Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
long-term (>3 to 6 months) · capsaicin oral rinse
MD -2.60 [-5.11, -0.09]
1 study · 18 participants
Very low