Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 1 reviews · Multiple Sclerosis and Rare Diseases of the CNS

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 22.2%Low 5 · 55.6%Moderate 2 · 22.2%High 0 · 0%

Summary of findings table ‐ Cannabis vs placebo

Spasticity: number of participants reporting reduction of 30% in the spasticity NRS ( · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher spasticity: number of participants reporting reduction of 30% in the… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Participant‐reported pain relief of 50% or greater · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes pain:number of participants reporting pain relief of 50% or greater… compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Patient Global Impression of Change much or very much improved · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher PGIC:number of participants reporting much or very much improvement… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Specific AEs: number of participants reporting drug tolerance ( · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes specific AEs: number of participants reporting drug tolerance ( compared with placebo (very low certainty).

1 finding from 1 review