CO2 laser combined with fluoride vs Fluorides alone (monotherapy)
Enamel demineralization (QLF ΔF) · Human enamel specimens under cariogenic challenge (in situ / ex vivo)
Evidence on a synergistic effect of combining CO2 laser with fluoride versus fluoride alone is mixed: one ex-vivo study found combined treatment superior while another found no synergy (ungraded, 2 ex-vivo studies, no pooled estimate).
1 finding from 1 review
- Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. 2024 All outcomesEx-vivo/in situ (laboratory)Narrative only (secondary question: laser-fluoride synergy). Takate: combined low-power CO2 laser plus 1.23% APF gave greater inhibition of mineral loss than either alone (APF after laser gave maximum inhibition).…2 studiesGRADE not reported