Findings

What do systematic reviews say?

7 questions · 9 findings · 2 reviews · Developmental, Psychosocial and Learning Problems

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 11.1%Low 4 · 44.4%Moderate 4 · 44.4%High 0 · 0%

Atypical antipsychotics vs placebo

Irritability · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 973 participants
Moderate

Atypical antipsychotics vs placebo

Aggression · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 77 participants
Very low

Atypical antipsychotics vs placebo

Self‐injury · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Atypical antipsychotics vs placebo

Adverse effects (AEs) · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

Atypical antipsychotics may leads to higher adverse effects (AEs) compared with placebo (low certainty).

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
RR 4.19
11 studies · 974 participants
Low

RISPERIDONE vs placebo

Aggression · Disruptive behaviours in children and youths

2 findings from 1 review

Atypical antipsychotics for disruptive behaviour disorders in children and youths 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 238 participants
Low
Atypical antipsychotics for disruptive behaviour disorders in children and youths 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 190 participants
Moderate

RISPERIDONE vs placebo

Conduct · Disruptive behaviours in children and youths

1 finding from 1 review

Atypical antipsychotics for disruptive behaviour disorders in children and youths 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 225 participants
Moderate

RISPERIDONE vs placebo

Weight gain · Disruptive behaviours in children and youths

2 findings from 1 review

Atypical antipsychotics for disruptive behaviour disorders in children and youths 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 138 participants
Moderate
Atypical antipsychotics for disruptive behaviour disorders in children and youths 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 305 participants
Low