Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

122 questions · 127 findings · 16 reviews · Skin · Headline outcomes only

No studies found 17 · 13.4%GRADE not reported 0 · 0%Very low 14 · 11%Low 54 · 42.5%Moderate 30 · 23.6%High 12 · 9.4%

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher physician assessment of success by analysing scores and scales compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in participant assessment success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 20U (high certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in physician assessment of success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 20U (high certainty).

1 finding from 1 review

Summary of Findings Table ‐ IncobotulinumtoxinA 24U vs OnabotulinumtoxinA 24U

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ IncobotulinumtoxinA 24U showed no clear difference in physician assessment of success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 24U (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo

Participant assessment of success by analysing scores and scales ‐ 20 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U leads to higher participant assessment of success by analysing scores and scales ‐… compared with placebo (high certainty).

1 finding from 1 review

NB‐UVB vs PUVA

Investigator Global Assessment · atopic eczema

It is very uncertain whether summary of findings table ‐ NB‐UVB changes investigator Global Assessment compared with PUVA (very low certainty).

1 finding from 1 review

UVA1 vs PUVA

Investigator Global Assessment ‐ not measured · atopic eczema

The review found no eligible studies for this question.

1 finding from 1 review

NB‐UVB vs placebo

Investigator Global Assessment · atopic eczema

Summary of findings table ‐ NB‐UVB may leads to higher investigator Global Assessment (short‐term) compared with placebo (low certainty).

1 finding from 1 review

NB‐UVB vs UVA1

Investigator Global Assessment ‐ not measured · atopic eczema

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs placebo or no treatment

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide may leads to higher participant's global self‐assessment of improvement (long‐term data) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Benzoyl peroxide vs erythromycin

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs adapalene

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with adapalene (low certainty).

1 finding from 1 review