Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 25 findings · 2 reviews · Pregnancy and Childbirth

No studies found 2 · 8%GRADE not reported 7 · 28%Very low 11 · 44%Low 5 · 20%Moderate 0 · 0%High 0 · 0%

Aspirin vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · women with perineal pain in the early postpartum period

Aspirin may leads to higher adequate pain relief as reported by the woman (4 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Need for additional pain relief (4 to 8 hours) · women with perineal pain in the early postpartum period

It is very uncertain whether aspirin changes need for additional pain relief (4 to 8 hours) compared with placebo (very low certainty).

1 finding from 1 review

Aspirin vs placebo

Adverse events in the mother ‐ Bleeding · women with persistent antiphospholipid antibodies and recurrent pregnancy loss

It is very uncertain whether aspirin changes adverse events in the mother ‐ Bleeding compared with placebo (very low certainty).

1 finding from 1 review

Aspirin vs placebo

Adverse events in the child ‐ Congenital malformations · women with persistent antiphospholipid antibodies and recurrent pregnancy loss

It is very uncertain whether aspirin changes adverse events in the child ‐ Congenital malformations compared with placebo (very low certainty).

1 finding from 1 review

Heparin plus aspirin vs aspirin

Adverse events in the mother ‐ Bleeding · women with persistent antiphospholipid antibodies and recurrent pregnancy loss

Heparin plus aspirin showed no clear difference in adverse events in the mother ‐ Bleeding compared with aspirin (low certainty).

1 finding from 1 review