Findings

What do systematic reviews say?

15 questions · 15 findings · 2 reviews · Neuromuscular

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No studies found 2 · 13.3%GRADE not reported 1 · 6.7%Very low 0 · 0%Low 0 · 0%Moderate 8 · 53.3%High 4 · 26.7%

Ascorbic acid vs placebo

Change in 10‐metre walking time · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 406 participants
Moderate

Ascorbic acid vs placebo

Change in 9‐hole peg test (HPT) at 12 months (seconds) · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 224 participants
Moderate

Ascorbic acid vs placebo

Health‐related quality of life (physical) · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 400 participants
Moderate

Ascorbic acid vs placebo

Participation · people with fatigue in peripheral neuropathy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ascorbic acid vs placebo

Health‐related quality of life (mental) · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Moderate

Ascorbic acid vs placebo

Serious adverse events · people with fatigue in peripheral neuropathy

Ascorbic acid showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
RR 0.7 [0.39, 1.27]
2 studies · 450 participants
Moderate

Ascorbic acid vs placebo

Reduction in fatigue · people with fatigue in peripheral neuropathy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ascorbic acid vs placebo

Fatigue · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 404 participants
Moderate

Ascorbic acid vs placebo

Change in activity limitations · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 406 participants
GRADE not reported

Intervention not reported

Impairment ‐ change in CMTNS at 24 months (0 to 36 points) · adults with CMT1A

1 finding from 1 review

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 388 participants
High

Intervention not reported

Impairment ‐ change in CMTES at 24 months (0 to 28 points) · adults with CMT1A

1 finding from 1 review

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 337 participants
Moderate

Intervention not reported

Change in timed 10‐m walk at 12 months (seconds (s)) · adults with CMT1A

1 finding from 1 review

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 401 participants
High

Intervention not reported

Change in foot dorsiflexion at 12 months (N) · adults with CMT1A

1 finding from 1 review

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 423 participants
High

Intervention not reported

Change in 9‐hole peg test (HPT) at 12 months (seconds) · adults with CMT1A

1 finding from 1 review

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 286 participants
Moderate

Intervention not reported

Serious adverse events (SAE; %) · adults with CMT1A

1 finding from 1 review

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 702 participants
High