Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 1 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

Any prophylaxis vs on‐demand treatment

Any reported adverse events · participants with haemophilia

Prophylaxis regimen probably leads to higher any reported adverse events compared with on‐demand treatment (moderate certainty).

1 finding from 1 review

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated… 2021 · Cochrane Headline outcomes only
RR 1.71 [1.24, 2.37]
2 studies · 131 participants
Moderate

Prophylaxis with standard therapeutic factor concentrate vs pegylated liposome FVIII formulation

Any reported adverse effects · children or adults with hemophilia A

1 finding from 1 review

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 143 participants
Low

Full‐mouth ultrasonic scaling plus photodynamic therapy vs full‐mouth ultrasonic scaling alone

Resolution or reduction in severity of any other dental complication: systemic infections (measured by number of episodes after treatment for dental complications under antibiotic prophylaxis) · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review

Treatment of dental and orthodontic complications in thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found