Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%

50% or greater reduction in seizure frequency · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide leads to higher 50% or greater reduction in seizure frequency compared with placebo (high certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 1.79 [1.55, 2.08]
5 studies · 2199 participants
High

Seizure freedom · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide may leads to higher seizure freedom compared with placebo (low certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 2.27 [1.35, 3.83]
5 studies · 2199 participants
Low

Treatment withdrawal · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide probably leads to higher treatment withdrawal compared with placebo (moderate certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 1.57 [1.24, 1.98]
5 studies · 2199 participants
Moderate

Dizziness · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide leads to higher dizziness compared with placebo (high certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 2.96
5 studies · 2199 participants
High

Headache · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide probably leads to higher headache compared with placebo (moderate certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 1.34
5 studies · 2199 participants
Moderate

Vomiting · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide probably leads to higher vomiting compared with placebo (moderate certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 2.94
5 studies · 2199 participants
Moderate

Serious adverse events · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide probably leads to higher serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Lacosamide add‐on therapy for focal epilepsy 2021 · Cochrane Headline outcomes only
RR 1.53
5 studies · 2199 participants
Moderate