Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 51 findings · 2 reviews · Skin

No studies found 8 · 15.7%GRADE not reported 1 · 2%Very low 2 · 3.9%Low 30 · 58.8%Moderate 10 · 19.6%High 0 · 0%

Fexofenadine 120 mg/d vs placebo (1‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Fexofenadine 120 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (1‐week intervention) (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs placebo (4‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Loratadine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

1 finding from 1 review

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · children with eczema

Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs placebo (2‐week intervention)

Secondary outcome 1. Physician‐assessed clinical signs Number for whom treatment success was judged as good or very good · adults with eczema

Loratadine 10 mg/d showed no clear difference in secondary outcome 1. Physician‐assessed clinical signs Number for… compared with placebo (2‐week intervention) (low certainty).

1 finding from 1 review