Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 2 · 33.3%GRADE not reported 2 · 33.3%Very low 0 · 0%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Anticoagulant with or without ASA vs ASA only

Thrombosis · people with antiphospholipid antibodies and no history of thrombosis

Anticoagulant with or without ASA showed no clear difference in thrombosis Median compared with ASA only (low certainty).

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
RR 0.98 [0.25, 3.77]
4 studies · 493 participants
Low

Anticoagulant with or without ASA vs ASA only

Major bleeding · people with antiphospholipid antibodies and no history of thrombosis

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 493 participants
GRADE not reported

Anticoagulant with or without ASA vs ASA only

Minor bleeding · people with antiphospholipid antibodies and no history of thrombosis

Anticoagulant with or without ASA may leads to higher bleeding ‐ minor (not requiring hospital admission) Median compared with ASA only (low certainty).

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
RR 22.45 [1.34, 374.81]
1 study · 164 participants
Low

Anticoagulant with or without ASA vs ASA only

All‐cause mortality · people with antiphospholipid antibodies and no history of thrombosis

The review found no eligible studies for this question.

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Anticoagulant with or without ASA vs ASA only

Quality of life · people with antiphospholipid antibodies and no history of thrombosis

The review found no eligible studies for this question.

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Anticoagulant with or without ASA vs ASA only

Adverse event other than bleeding · people with antiphospholipid antibodies and no history of thrombosis

Anticoagulant with or without ASA led to lower adverse event other than bleeding compared with ASA only; GRADE not reported.

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
no estimate extracted
2014 participants
GRADE not reported