What do systematic reviews say?

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 0.44 [0.19, 1.00]
  5 studies · 1107 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 0.69 [0.36, 1.35]
  6 studies · 1162 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  4 months
  RR 0.33 [0.16, 0.67]
  6 studies · 1162 participants
  Moderate

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 1.0 [0.06, 15.85]
  6 studies · 1162 participants
  GRADE not reported

Implant surface smoothening added to systemic antibiotics + resective surgery + local antibiotics vs No implant surface smoothening (same surgical protocol)

Implant surface smoothening added to systemic antibiotics +… showed no clear difference in implant failure compared with no implant surface smoothening (same surgical protocol); GRADE not reported.

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  2 years
  RR 0.3 [0.01, 6.47]
  1 study · 17 participants
  GRADE not reported

Implant surface smoothening added to systemic antibiotics + resective surgery + local antibiotics vs No implant surface smoothening (same surgical protocol)

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  2 years
  No complications occurred in any of the groups.
  1 study · 17 participants
  GRADE not reported

Prophylactic antibiotic at one dose or duration vs Same antibiotic at a different dose or duration

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 months
  No conclusive information can be derived from the only trial that compared three different durations of antibiotic prophylaxis, since no event (implant or prosthesis failures, infections or adverse events) occurred in…
  1 study · 100 participants
  GRADE not reported

One prophylactic antibiotic vs A different prophylactic antibiotic

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  At least 3 months (planned)
  no estimate extracted
  0 studies
  No studies found