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Evidence found and GRADE certainty

5 questions · 5 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 1 · 20%High 1 · 20%

Amphotericin B deoxycholate vs liposomal amphotericin B: effects on kidney function

Increase in SCr level: ≥ two‐fold from baseline level SCr level (mg/dL) · patients in treatment with amphotericin B

Amphotericin B deoxycholate probably leads to lower increase in SCr level: ≥ two‐fold from baseline level SCr level… compared with liposomal amphotericin B: effects on kidney function (moderate certainty).

1 finding from 1 review

Induction: liposomal amphotericin vs Amphotericin B

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · adults with HIV and progressive disseminated histoplasmosis

Induction: liposomal amphotericin may leads to higher clinical success compared with amphotericin deoxycholate (low certainty).

1 finding from 1 review

Induction: liposomal amphotericin vs Amphotericin B

Safety outcomes: drug discontinuation · adults with HIV and progressive disseminated histoplasmosis

It is very uncertain whether induction: liposomal amphotericin changes safety outcomes: drug discontinuation compared with amphotericin deoxycholate (very low certainty).

1 finding from 1 review