Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 1 reviews · Childhood Cancer · Headline outcomes only

No studies found 5 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 50%Moderate 0 · 0%High 0 · 0%

Amifostine vs no otoprotective intervention

Ototoxicity according to NCI CTC v2 criteria with intra‐arterial platinum (combined asymptomatic and symptomatic disease) Exact test method not reported · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intra‐arterial… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Ototoxicity according to NCI CTC v2 criteria with intravenous platinum (combined asymptomatic and symptomatic disease) Objective and subjective audiometric evaluations were performed, no further information provided · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intravenous platinum… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Ototoxicity according to modified Brock criteria with intravenous platinum (combined asymptomatic and symptomatic disease) Audiograms were performed, but no further information provided · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to modified Brock criteria with intravenous… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Tumour response with intra‐arterial platinum (good and partial remission) · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in tumour response with intra‐arterial platinum (good and partial… compared with no otoprotective intervention (low certainty).

1 finding from 1 review