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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Childhood Cancer

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%

Summary of findings: urate oxidase vs allopurinol

Incidence of clinical tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase showed no clear difference in incidence of clinical tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Mortality due to tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase may leads to lower mortality due to tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Organ system failure ‐ Renal insufficiency leading to replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome

It is very uncertain whether summary of findings: urate oxidase changes renal failure requiring renal replacement therapy ( compared with allopurinol (very low certainty).

1 finding from 1 review