Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 92 findings · 9 reviews · Headline outcomes only

No studies found 45 · 48.9%GRADE not reported 1 · 1.1%Very low 4 · 4.3%Low 21 · 22.8%Moderate 14 · 15.2%High 7 · 7.6%

Allopurinol vs placebo

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with benzbromarone (low certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Proportion achieving target serum urate · people with chronic gout

Allopurinol showed no clear difference in proportion achieving target serum urate compared with benzbromarone (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Proportion achieving target serum urate · people with chronic gout

Allopurinol probably leads to higher proportion achieving target serum urate compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with benzbromarone (low certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Serious adverse effects · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Function · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Tophus regression · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs placebo

Serious adverse events · people with chronic gout

Allopurinol showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review