Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 30 findings · 2 reviews · Musculoskeletal · Headline outcomes only

No studies found 12 · 40%GRADE not reported 0 · 0%Very low 2 · 6.7%Low 9 · 30%Moderate 7 · 23.3%High 0 · 0%

Tramadol in combination with acetaminophen vs placebo

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).

1 finding from 1 review

Tramadol vs paracetamol

Outcomesa · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review