What do systematic reviews say?

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  12 months
  Adverse effects of toothpaste: not estimable. "There were no reports on adverse effects, but some children complained about the taste of the dentifrice" (Cardoso 2014); 195 participants (1 RCT); low-certainty.
  1 study · 195 participants
  Low

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

1055 to 1100 ppm F toothpaste may leads to lower proportion developing new caries compared with 500 to 550 ppm F toothpaste (low certainty).

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  36 months
  RR 0.86 [0.74, 0.99]
  1 study · 905 participants
  Low

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

1055 to 1100 ppm F toothpaste showed no clear difference in caries increment, tooth index d(m)ft compared with 500 to 550 ppm F toothpaste (low certainty).

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  Follow-up: 36 months
  MD -0.27 [-0.6, 0.06]
  1 study · 905 participants
  Low

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

1055 to 1100 ppm F toothpaste showed no clear difference in caries increment, surface index d(m)fs compared with 500 to 550 ppm F toothpaste (moderate certainty).

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  Follow-up: 20 to 36 months
  MD -0.05 [-0.38, 0.28]
  2 studies · 1958 participants
  Moderate