Adverse effects: allergy to local anaesthetic · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
2 findings from 1 review
SoF: Not measured.
0 studies
No studies found
SoF: See comment (orphan study; unclear whether data relate to just solution deposition; SDs not reported); 18 participants, 36 interventions (1 study). Not pooled/graded.
1 study · 18 participants
GRADE not reported
Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
SoF: See comment, not estimable (orphan study; duration of follow-up not reported); 100 participants, 100 interventions (1 study). Not pooled/graded.
1 study · 100 participants
GRADE not reported
Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine may leads to higher speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
'Other comparisons with 100% success': IANB - Sampaio 2012 35/35 vs 35/35; Fernandez 2005 39/39 vs 39/39. Both formulations 100% successful; no meta-analysis (no difference).
2 studies · 74 participants
GRADE not reported
Adverse effects: paraesthesia following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Complete remission, pain intensity, patient and physician evaluation · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
One trial at high risk of bias (de Abreu 2009) compared clofazimine (n=23) with colchicine (n=23). The number with no further aphthous episodes at 6 months was significantly greater in the clofazimine group than the…
1 study · 46 participants
GRADE not reported
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
Clofazimine was associated with an increase in cutaneous adverse effects (Fisher's exact test P=0.015), easily controlled; there was a greater percentage of treatment interruptions in the colchicine group due to…
1 study · 46 participants
GRADE not reported
Complete remission (no further aphthous episodes to 6 months) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
The trial by de Abreu 2009 (high risk of bias) also assessed colchicine (n=23) versus placebo (n=20). The number with no further aphthous episodes at 6 months was not significantly different from placebo (Fisher's…
1 study · 43 participants
GRADE not reported
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
There was a greater percentage of treatment interruptions in the colchicine group due to gastrointestinal adverse effects (Fisher's exact test P=0.009). The review noted potential evidence of harm at a dose of 1.5 mg…
1 study · 43 participants
GRADE not reported
Pain at completion of treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Colchicine (0.5 mg per day for 3 months) showed no clear difference in pain at completion of treatment compared with prednisolone (5 mg per day for 3 months); GRADE not reported.
1 finding from 1 review
Number of (minor aphthous) oral ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Colchicine (0.5 mg per day for 3 months) showed no clear difference in number of aphthous ulcers at completion compared with prednisolone (5 mg per day for 3 months); GRADE not reported.
1 finding from 1 review
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
Colchicine was associated with statistically significantly more adverse effects than prednisolone (nine participants reporting adverse effects on colchicine versus two on prednisolone).
1 study · 34 participants
GRADE not reported
Recurrence · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Colchicine (0.5 mg per day for 3 months) showed no clear difference in recurrence during treatment period compared with prednisolone (5 mg per day for 3 months); GRADE not reported.
1 finding from 1 review
Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether benzodiazepines (systemic clonazepam 0.5 mg/day) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).
1 finding from 1 review