Fractures: vertebral or deformity · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: vertebral or deformity, Men aged >65 years and postmenopausal women: RR 0.90 (95% CI 0.42 to 1.92), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Bone mineral density in forearm · Community dwelling adults
The meta-analysis of RCTs reported a WMD of -0.70 (95% CI 1.70 to 0.40) for vitamin d supplementation versus control.
1 finding from 1 review
WMD -0.70 [-1.70, 0.40]
2 studies
GRADE not reported
Ovarian cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Ovarian cancer: OR 0.83 (95% CI 0.63 to 1.09), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Stroke · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Stroke: RR 0.61 (95% CI 0.50 to 0.75), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Breast cancer · Participants in observational studies
The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.68 to 1.47) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Colon cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Colon cancer: OR 0.78 (95% CI 0.56 to 1.07), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Cholesterol mg/dL · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Total cholesterol: WMD 1.52 (95% CI -1.42 to 4.46), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD 1.52 [-1.42, 4.46]
11 studies
GRADE not reported
Parathyroid hormone · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroid hormone: WMD -196.05 (95% CI -298.43 to -93.66), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
Risk of requiring dialysis · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of requiring dialysis: RR 0.76 (95% CI 0.36 to 1.62), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Colorectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Colorectal cancer: RR 0.70 (95% CI 0.58 to 0.84), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Parathyroid hormone · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroid hormone: WMD -49.34 (95% CI -85.70 to -12.97), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Mortality (all cause) · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Mortality (all cause) (Vitamin D2, general population): RR 1.04 (95% CI 0.97 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
2 findings from 1 review
Performance measures: balance sway · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Performance measures: balance sway, Older adults: SMD -0.20 (95% CI -0.39 to -0.01), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
SMD -0.20 [-0.39, -0.01]
3 studies
GRADE not reported
Performance measures: lower extremity strength · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Performance measures: lower extremity strength, Older adults: SMD 0.05 (95% CI -0.11 to 0.20), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.05 [-0.11, 0.20]
3 studies
GRADE not reported
CVD · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease: RR 0.66 (95% CI 0.57 to 0.77), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Depression · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Depression (Cohort studies): HR 0.44 (95% CI 0.27 to 0.72), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
2 findings from 1 review
Vascular calcification · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Vascular calcification: RR 1.09 (95% CI 0.45 to 2.67), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All‐cause mortality · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Mortality: RR 1.34 (95% CI 0.34 to 5.24), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Serum fasting triglyceride (TG, mmol/L) · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Triglycerides: WMD -1.92 (95% CI -7.72 to 3.88), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -1.92 [-7.72, 3.88]
8 studies
GRADE not reported
Breast cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Breast cancer: OR 0.99 (95% CI 0.68 to 1.44), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review