Pancreatic cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Pancreatic cancer: OR 2.13 (95% CI 1.02 to 4.47), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Hip Fracture · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Hip fracture (Population-based controls): log ratio of geometric mean -0.51 (95% CI -0.64 to -0.38), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
2 findings from 1 review
log ratio of geometric mean -0.51 [-0.64, -0.38]
9 studies · 1655 participants
GRADE not reported
log ratio of geometric mean -0.26 [-0.33, -0.23]
8 studies · 2201 participants
GRADE not reported
Non-Hodgkin's lymphoma · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Non-Hodgkin's lymphoma (Females): OR 0.81 (95% CI 0.39 to 1.70), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
2 findings from 1 review
Hypertension · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Hypertension: RR 0.70 (95% CI 0.58 to 0.86), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Aggressive prostate cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Aggressive prostate cancer: OR 0.98 (95% CI 0.84 to 1.15), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Cardiovascular mortality · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease mortality: RR 0.55 (95% CI 0.36 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Birth length · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth length: WMD 0.19 (95% CI -0.26 to 0.65), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Subperiosteal erosions · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Subperiosteal erosions: RR 0.41 (95% CI 0.07 to 2.38), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All‐cause mortality · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Mortality: RR 1.40 (95% CI 0.38 to 5.15), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Colorectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Colorectal cancer: OR 1.01 (95% CI 0.59 to 1.73), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
OR 1.01 [0.59, 1.73]
4 studies
GRADE not reported
Cardiovascular disease (prevalent) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease (prevalent): OR 0.67 (95% CI 0.55 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Small‐for‐gestational age · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Small for gestational age: RR 0.67 (95% CI 0.40 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Creatinine clearance · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Creatinine clearance: WMD -1.68 (95% CI -6.92 to 3.56), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -1.68 [-6.92, 3.56]
4 studies
GRADE not reported
Risk of hyperphosphataemia · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hyperphosphataemia: RR 1.57 (95% CI 0.97 to 2.54), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Fracture · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: RR 1.00 (95% CI 0.06 to 15.41), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
RR 1.00 [0.06, 15.41]
4 studies
GRADE not reported
Hypercalcaemia · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hypercalcaemia: RR 3.04 (95% CI 1.17 to 7.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Bone mineral density in forearm · children
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in forearm, Healthy children: SMD 0.04 (95% CI -0.36 to 0.45), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.04 [-0.36, 0.45]
3 studies
GRADE not reported
Tuberculosis · Participants in observational studies
The meta-analysis of observational studies reported a SMD (to OR) of 0.29 (95% CI 0.19 to 0.46) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Preterm birth · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Preterm delivery: RR 0.77 (95% CI 0.35 to 1.66), not statistically significant.
1 finding from 1 review
Birthweight (g) · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth weight: WMD 130.9 (95% CI 75.1 to 186.7), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review