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What do systematic reviews say?

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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Rivaroxaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Dabigatran (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure

Wound infection · pilonidal sinus

It is very uncertain whether summary of findings table ‐ Off‐midline closure changes wound infection compared with tension‐free midline closure (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure

Wound dehiscence · pilonidal sinus

It is very uncertain whether summary of findings table ‐ Off‐midline closure changes wound dehiscence compared with tension‐free midline closure (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Proportion of wounds healed · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in proportion of wounds healed compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Recurrence · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in recurrence rate compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Wound infection · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in wound infection compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Wound dehiscence · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in wound dehiscence compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure vs conventional midline closure

Proportion of wounds healed · pilonidal sinus

It is very uncertain whether summary of findings table ‐ Off‐midline closure changes proportion of wounds healed compared with conventional midline closure (very low certainty).

1 finding from 1 review