Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,545 questions · 2,661 findings · 317 reviews

No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Intervention not reported

Teriflunomide (Direct evidence; 2 RCTs; 2253 participants) · Patients with RRMS Interventions: Alemtuzumab, cladribine, daclizumab, dimethylfumarate, fingolimod, glatiramer acetate, interferon…

It is very uncertain whether the intervention changes teriflunomide (Direct evidence; 2 RCTs; 2253 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

RT vs supportive care only · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention probably leads to lower RT vs supportive care only (moderate certainty).

1 finding from 1 review

Intervention not reported

Hypofractionated RT vs standard RT (60Gy/30 fractions) · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention led to lower hypofractionated RT vs standard RT (60Gy/30 fractions); GRADE not reported.

1 finding from 1 review

Intervention not reported

TMZ vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention showed no clear difference in TMZ vs RT (low certainty).

1 finding from 1 review

Intervention not reported

CRT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention leads to lower CRT vs RT (high certainty).

1 finding from 1 review

Intervention not reported

BEV_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention showed no clear difference in BEV_CRT vs CRT (low certainty).

1 finding from 1 review