Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

FLUPENTHIXOL DECANOATE VERY LOW (˜6 mg/IM) DOSE vs FLUPENTHIXOL DECANOATE LOW DOSE (˜9 mg/IM)

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short/medium term ‐ not reported · patients with schizophrenia or related psychoses

The review found no eligible studies for this question.

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Leaving the study early ‐ short/medium term Rate of attrition · patients with schizophrenia or related psychoses

It is very uncertain whether FLUPENTHIXOL DECANOATE changes leaving the study early ‐ short term Rate of attrition compared with ORAL ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short term Numbers requiring anticholinergic medication · patients with schizophrenia or related psychoses

It is very uncertain whether FLUPENTHIXOL DECANOATE changes adverse effects: general ‐ movement disorders ‐ requiring… compared with ORAL ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

Clinical response: mental state ‐ relapse ‐ medium term Relapse rate · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE showed no clear difference in clinical response: mental state ‐ relapse ‐ medium term Relapse rate compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

Perazine vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether perazine changes acceptability of treatment Leaving the study early due to any reason compared with placebo (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Movement disorders number of participants receiving antiparkinson medication · patients with schizophrenia

It is very uncertain whether perazine changes movement disorders number of participants receiving antiparkinson… compared with other antipsychotics (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

Perazine showed no clear difference in overall tolerability Leaving the study early due to adverse events compared with other antipsychotics (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Perazine showed no clear difference in acceptability of treatment Leaving the studies early due to any reason compared with other antipsychotics (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Satisfaction with care ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Quality of life ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs placebo

Global state change over time (no better or deterioration) · patients with schizophrenia

Perazine may leads to lower global state change over time (no better or deterioration) compared with placebo (low certainty).

1 finding from 1 review

Perazine vs placebo

Mental state: 2. Not improved (BPRS, < 30% decrease in BPRS score) · patients with schizophrenia

Perazine showed no clear difference in overall mental state less than 30% BPRS reduction compared with placebo (low certainty).

1 finding from 1 review