Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,556 questions · 2,794 findings · 119 reviews · Oral Health

No studies found 489 · 17.5%GRADE not reported 1,719 · 61.5%Very low 399 · 14.3%Low 128 · 4.6%Moderate 58 · 2.1%High 1 · 0%

Multivitamin vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in mean number of new lesions compared with placebo; GRADE not reported.

1 finding from 1 review

Tooth/implant FDP with rigid connectors vs Tooth/implant FDP with non-rigid connectors

Prosthesis survival and crestal bone loss (5 years) · Patients with tooth/implant-supported FDPs; split-mouth
1 finding from 1 review

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Pain at completion of treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Colchicine (0.5 mg per day for 3 months) showed no clear difference in pain at completion of treatment compared with prednisolone (5 mg per day for 3 months); GRADE not reported.

1 finding from 1 review

Fixed dental prosthesis (cantilever FDP) vs Removable dental prosthesis (RDP)

5-year prosthesis survival · Patients with a shortened dental arch (missing posterior teeth)

Fixed dental prosthesis (cantilever FDP) showed no clear difference in prosthesis survival compared with removable dental prosthesis (RDP); GRADE not reported.

1 finding from 1 review

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

Total number of new lesions over 2-month treatment period · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Prednisone (oral, commencing 25 mg with phased dose reduction over 2… led to lower total number of new lesions over 2-month treatment period compared with placebo; GRADE not reported.

1 finding from 1 review

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Side effects · People with erosive oral lichen planus
1 finding from 1 review
  • Table 3 (Side-effects). Malhotra 2008: betamethasone oral mini-pulse - transient oedema over the face (7), oedema over hands and feet (4), epigastric discomfort (7), weakness/fatigue (5), loose stools (1), headache…
    1 study · 22 participants
    GRADE not reported

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis

Er:YAG laser led to lower recurrence of peri-implantitis compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review

Camel thorn (plant distillate) vs placebo

Pain intensity and lesion diameter · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

Days to resolution of pain / epithelialization; number of aphthae per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Femiano 2003 (high risk of bias) reports days to resolution of pain and days to epithelialization of aphthae at 1 month, and number of aphthae per month after the first and second months; data presented as…
    1 study · 20 participants
    GRADE not reported

Beta-glucan (1.3/1.6 beta-glucan 10 mg twice daily for 20 days) vs placebo

Ulcer severity score (USS) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Beta-glucan (1.3/1.6 beta-glucan 10 mg twice daily for 20 days) led to lower ulcer severity score (USS) compared with placebo; GRADE not reported.

1 finding from 1 review

Camel thorn (plant distillate) vs placebo

Ulcer healing · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • A single trial (Pourahmad 2010, unclear risk of bias) randomised 93 participants to camel thorn distillate (n=49) or placebo (n=44). Mean time to complete resolution was 4.02 days (range 3 to 7) for camel thorn…
    1 study · 93 participants
    GRADE not reported

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing attachment level (PAL) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing attachment level (PAL) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis
1 finding from 1 review

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser showed no clear difference in change in probing pocket depth compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review