Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

2,545 questions · 2,661 findings · 317 reviews

No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Augmentation procedure (partial) failure · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in augmentation procedure (partial) failure compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous inlay bone graft (iliac crest)

Complications · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in complications compared with autogenous inlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Complication at augmentation + donor site · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in complication at augmented + donor site compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Vertical distraction osteogenesis vs Vertical GBR with non-resorbable barriers + particulate autogenous bone

Complication at augmentation + donor site · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in complication at augmentation + donor site compared with vertical GBR with non-resorbable barriers + particulate autogenous…; GRADE not reported.

1 finding from 1 review

Intervention not reported

Pegylated interferon beta‐1a (Direct evidence; 1 RCT; 1512 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins, interferon beta 1a ‐1b,…

The intervention may leads to lower pegylated interferon beta‐1a (Direct evidence; 1 RCT; 1512… (low certainty).

1 finding from 1 review

Intervention not reported

Natalizumab (Direct evidence; 1 RCT; 942 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins, interferon beta 1a ‐1b,…

The intervention leads to lower natalizumab (Direct evidence; 1 RCT; 942 participants) (high certainty).

1 finding from 1 review

Intervention not reported

Teriflunomide (Direct evidence; 1 RCT; 1169 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins, interferon beta 1a ‐1b,…

The intervention may leads to lower teriflunomide (Direct evidence; 1 RCT; 1169 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Azathioprine (Direct evidence; 1 RCT; 59 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

It is very uncertain whether the intervention changes azathioprine (Direct evidence; 1 RCT; 59 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cladribine (Direct evidence; 1 RCT; 1326 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

The intervention leads to lower cladribine (Direct evidence; 1 RCT; 1326 participants) (high certainty).

1 finding from 1 review

Intervention not reported

Dimethylfumarate (Direct evidence; 2 RCTs; 2307 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

The intervention probably leads to lower dimethylfumarate (Direct evidence; 2 RCTs; 2307 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Azathioprine (Direct evidence; 1 RCT; 59 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins, interferon beta 1a ‐1b,…

It is very uncertain whether the intervention changes azathioprine (Direct evidence; 1 RCT; 59 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Fingolimod (Direct evidence; 2 RCTs; 2355 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

The intervention probably leads to lower fingolimod (Direct evidence; 2 RCTs; 2355 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Glatiramer acetate (Direct evidence; 3 RCsT; 1014 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

The intervention probably leads to lower glatiramer acetate (Direct evidence; 3 RCsT; 1014 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Immunoglobulins (Direct evidence; 2 RCTs; 192 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

The intervention may leads to lower immunoglobulins (Direct evidence; 2 RCTs; 192 participants) (low certainty).

1 finding from 1 review