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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,653 questions in 194 reviews · Gynaecology and Fertility
current versionsNo studies 531 · 20%Ungraded 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Pain during the procedure · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI) Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination (2022) · Cochrane | no estimate extracted | NR | No studies |
Progesterone vs no treatment or placebo (route of progesterone administration) Outcomes* · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Progesterone vs placebo/no treatment Clinical pregnancy rate · women with gonadotropin stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.38 [1.1, 1.74] | 7 studies · 1437 participants | Low |
Progesterone vs placebo/no treatment Multiple pregnancy rate · women with gonadotropin stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.72 [0.17, 3.15] | 1 study · 214 participants | Low |
Progesterone vs placebo/no treatment Adverse events, OHSS, preterm delivery, congenital anomaly · women with gonadotropin stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Progesterone vs placebo/no treatment Live birth rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Progesterone vs placebo/no treatment Ongoing pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.73 [0.37, 1.42] | 1 study · 253 participants | Low |
Progesterone vs placebo/no treatment Miscarriage rate per clinical pregnancy · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.67 [0.3, 1.5] | 2 studies · 123 participants | Low |
Progesterone vs placebo/no treatment Clinical pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.4 [1.03, 1.9] | 4 studies · 733 participants | Low |
Progesterone vs placebo/no treatment Multiple pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.44 [0.24, 8.49] | 1 study · 290 participants | Low |
Progesterone vs placebo/no treatment Adverse events, OHSS, preterm delivery, congenital anomaly · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Progesterone vs placebo/no treatment Live birth rate/ongoing pregnancy · women with oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.97 [0.58, 1.64] | 2 studies · 485 participants | Low |
Progesterone vs no treatment or placebo (route of progesterone administration) Live birth/ongoing pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.1 [0.81, 1.48] | 7 studies · 1792 participants | Low |
Progesterone vs placebo/no treatment Miscarriage rate per clinical pregnancy · women with oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.53 [0.25, 1.14] | 2 studies · 119 participants | Low |
Progesterone vs placebo/no treatment Clinical pregnancy · women with oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.44 [1.04, 1.98] | 6 studies · 1073 participants | Low |
Progesterone vs placebo/no treatment Multiple pregnancy · women with oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.58 [0.1, 3.55] | 2 studies · 586 participants | Low |
Progesterone vs placebo/no treatment Adverse events, OHSS, preterm delivery, congenital anomaly · women with oral (clomiphene citrate or letrozole) stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
300 mg vaginal progesterone vs 600 mg vaginal progesterone Ongoing pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.58 [0.81, 3.09] | 1 study · 200 participants | Very low |
300 mg vaginal progesterone vs 600 mg vaginal progesterone Multiple pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.5 [0.05, 5.43] | 1 study · 200 participants | Very low |
Intramuscular (IM) progesterone vs vaginal progesterone Live birth rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Intramuscular (IM) progesterone vs vaginal progesterone Ongoing pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.59 [0.34, 1.02] | 1 study · 225 participants | Very low |
Intramuscular (IM) progesterone vs vaginal progesterone Miscarriage rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.75 [0.43, 1.32] | 1 study · 81 participants | Very low |
Intramuscular (IM) progesterone vs vaginal progesterone Clinical pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.78 [0.55, 1.11] | 1 study · 225 participants | Very low |
Progesterone vs no treatment or placebo (route of progesterone administration) Miscarriage per clinical pregnancy · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.7 [0.4, 1.25] | 5 studies · 261 participants | Low |
Intramuscular (IM) progesterone vs vaginal progesterone Multiple pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Intramuscular (IM) progesterone vs vaginal progesterone Adverse events  · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 9.25 [2.21, 38.78] | 1 study · 225 participants | Very low |
Intramuscular (IM) progesterone vs vaginal progesterone OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Oral progesterone vs vaginal progesterone Live birth rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Oral progesterone vs vaginal progesterone Ongoing pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.25 [0.7, 2.22] | 1 study · 150 participants | Very low |
Oral progesterone vs vaginal progesterone Miscarriage rate per clinical pregnancy · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.58 [0.11, 3.09] | 1 study · 41 participants | Very low |
Oral progesterone vs vaginal progesterone Clinical pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.16 [0.69, 1.96] | 1 study · 150 participants | Very low |
Oral progesterone vs vaginal progesterone Multiple pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Oral progesterone vs vaginal progesterone Adverse events, OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Aqueous subcutaneous (Sc) progesterone vs vaginal progesterone gel Ongoing pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.05 [0.54, 2.05] | 1 study · 246 participants | Very low |
Progesterone vs no treatment or placebo (route of progesterone administration) Clinical pregnancy per woman · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.35 [1.14, 1.61] | 13 studies · 2794 participants | Low |
Aqueous subcutaneous (Sc) progesterone vs vaginal progesterone gel Clinical pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.12 [0.59, 2.11] | 1 study · 246 participants | Very low |
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment Live birth · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment Ongoing pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.1 [0.7, 1.74] | 1 study · 291 participants | Very low |
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment Miscarriage rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.73 [0.26, 2.1] | 2 studies · 79 participants | Very low |
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment Clinical pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1 [0.68, 1.47] | 2 studies · 340 participants | Very low |
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment Multiple pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.28 [0.11, 0.7] | 2 studies · 126 participants | Very low |
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment Adverse events, OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Vaginal progesterone vs gonadotropin‐releasing hormone (GnRH) agonist Clinical pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1 [0.51, 1.95] | 1 study · 242 participants | Very low |
Human chorionic gonadotropin (hCG) injection vs no treatment Clinical pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.93 [0.4, 2.13] | 1 study · 130 participants | Very low |
Human chorionic gonadotropin (hCG) injection vs no treatment Multiple pregnancy rate · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.03 [0.22, 4.92] | 1 study · 130 participants | Very low |
Progesterone vs no treatment or placebo (route of progesterone administration) Clinical pregnancy per woman ‐ oral route · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.67 [0.4, 1.13] | 1 study · 99 participants | Very low |
Progesterone vs no treatment or placebo (route of progesterone administration) Multiple pregnancy per woman · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.84 [0.3, 2.34] | 3 studies · 956 participants | Low |
Progesterone vs no treatment or placebo (route of progesterone administration) Adverse events, OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | no estimate extracted | NR | No studies |
Progesterone vs placebo/no treatment Live birth rate/ongoing pregnancy rate · women with gonadotropin stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 1.24 [0.8, 1.92] | 4 studies · 1054 participants | Low |
Progesterone vs placebo/no treatment Miscarriage rate per clinical pregnancy · women with gonadotropin stimulation Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse (2022) · Cochrane | RR 0.68 [0.24, 1.91] | 2 studies · 102 participants | Low |