Findings

What do systematic reviews say?

335 questions · 344 findings · 21 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 95 · 27.6%GRADE not reported 22 · 6.4%Very low 48 · 14%Low 100 · 29.1%Moderate 55 · 16%High 24 · 7%

Intervention diet vs usual on‐treatment diet

High‐fibre diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention diet vs usual on‐treatment diet

Low‐fibre diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention diet vs usual on‐treatment diet

Low‐fat diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention diet vs usual on‐treatment diet

Mean GI symptom scores (Vaizey scale) (higher scores better) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Diet interventions showed no clear difference in mean GI symptom scores (Vaizey scale) (higher scores better) compared with usual on‐treatment diet (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low

Intervention diet vs usual on‐treatment diet

Diarrhoea · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention diet vs usual on‐treatment diet

Prebiotic diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dietary modifications (counselling or dietary change) vs no nutritional intervention

Diarrhoea · People undergoing RT for pelvic cancer

Dietary modification probably leads to lower diarrhoea at end of treatment compared with no nutritional intervention (moderate certainty).

1 finding from 1 review

Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy 2013 · Cochrane Headline outcomes only
RR 0.66 [0.51, 0.87]
4 studies · 413 participants
Moderate

Dietary modifications (counselling or dietary change) vs no nutritional intervention

Change in weight (kg) · People undergoing RT for pelvic cancer

1 finding from 1 review

Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 235 participants
Moderate

Intervention not reported

Supportive care only*** (1 RCT, 81 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
GRADE not reported

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention showed no clear difference in TMZ (3 RCTs, 538 participants) (low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.95 [0.71, 1.26]
3 studies · 538 participants
Low

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention leads to lower CRT (2 RCTs; 635 participants) (high certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.67 [0.56, 0.8]
2 studies · 635 participants
High

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention probably leads to lower BEV_CRT (1 RCT; 73 participants) (moderate certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.56 [0.31, 0.99]
1 study · 73 participants
Moderate

Intervention not reported

RT 60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 60 participants
GRADE not reported

Intervention not reported

RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention showed no clear difference in RT 40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.94 [0.72, 1.23]
4 studies · 40 participants
Low

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes BEV_RT (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 1.01 [0.58, 1.79]
1 study · 75 participants
Very low

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes TMZ (3 RCTs, 538 participants) (very low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.89 [0.71, 1.11]
3 studies · 538 participants
Very low

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention may leads to lower CRT (2 RCTs; 635 participants) (low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.63 [0.46, 0.87]
2 studies · 635 participants
Low

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.52 [0.28, 0.98]
1 study · 73 participants
GRADE not reported

Intervention not reported

RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention probably leads to lower RT60 (5 RCTs; 713 participants) (moderate certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.47 [0.29, 0.76]
5 studies · 60 participants
Moderate

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants); GRADE not reported.

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.48 [0.23, 1]
1 study · 75 participants
GRADE not reported