Findings

What do systematic reviews say?

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

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No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

N‐acetylcysteine vs placebo

Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 58 participants
Low

Ketamine vs placebo

Depression rating scale score · adults (aged 18 years+) with depression in bipolar disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 28 participants
Very low

Riluzole vs placebo

Depression rating scale scores ‐ not reported · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ketamine vs midazolam

Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Esketamine vs placebo

Depressive symptoms · adults with Major Depressive Disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Ketamine vs placebo

Depressive symptoms · adults with Major Depressive Disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Ketamine vs midazolam

Depressive symptoms · adults with Major Depressive Disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Discontinuation by "tapering" vs usual family planning care

Depressive symptoms · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1017 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Successful discontinuation rate · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 690 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Depressive symptoms · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 484 participants
Low

Behavioural activation vs third‐wave CBT

depression symptoms (continuous) up to 6 months (4‐8 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 147 participants
Low

Behavioural activation vs humanistic therapy

depression symptoms(continuous) up to 6 months (1 to 10 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 93 participants
Moderate

Behavioural activation vs psychodynamic therapies

depression symptoms(continuous) up to 6 months (12 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Behavioural activation vs interpersonal, cognitive analytic, integrative

depression symptoms (continuous) up to 6 months (4‐12 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 103 participants
Very low

Behavioural activation vs waiting list control

depression symptoms(continuous) up to 6 months (1 to 10 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 619 participants
Low

Behavioural activation vs CBT

depression symptoms (continuous) up to 6 months (4‐16 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 1205 participants
Moderate

Behavioural activation vs placebo

depression symptoms(continuous) up to 6 months (2 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 108 participants
Low

Behavioural activation vs medication

depression symptoms(continuous) up to 6 months (12 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 180 participants
Low

Behavioural activation vs no treatment

depression symptoms(continuous) up to 6 months (2‐5 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 187 participants
Moderate

Behavioural activation vs treatment

depression symptoms (continuous) up to 6 months (4‐8 weeks) · depression in adults

1 finding from 1 review

Behavioural activation therapy for depression in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 2208 participants
Low