Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Some components of shared decision‐making, including clarification of values and preferences, vs control

Choice of an option aligned with each woman’s values and preferences · women aged 38 to 71 years at average to moderate risk of breast cancer

The review found no eligible studies for this question.

1 finding from 1 review

Studies focused only on enhanced communication, without clarification of values and preferences, vs control

Choice of an option aligned with each woman’s values and preferences · women aged 40 to 75 years at average to moderate risk of breast cancer

The review found no eligible studies for this question.

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Death at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment showed no clear difference in death at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

End‐stage renal disease · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to lower end‐stage kidney disease at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher total remission (complete or partial) at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Complete remission · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher complete remission at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Relapse · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment may leads to higher recurrence of disease (relapse) at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (low certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

100% increase in SCr at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to lower 100% increase in serum creatinine at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Adverse events ‐ temporary or permanent discontinuation/hospitalisation at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher adverse events: temporary/permanent discontinuation or… compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Adverse events: infection at 3 years · primary membranous nephropathy in adults with nephrotic syndrome

It is very uncertain whether immunosuppressive treatment changes adverse events: infection at 3 years compared with placebo/no treatment/non‐immunosuppressive supportive treatment (very low certainty).

1 finding from 1 review