Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

314 questions · 335 findings · 34 reviews · Headline outcomes only

No studies found 57 · 17%GRADE not reported 2 · 0.6%Very low 87 · 26%Low 114 · 34%Moderate 60 · 17.9%High 15 · 4.5%

Intervention not reported

Retransplantation after start of therapy ‐ interferon vs.control · Participants with recurrent liver graft infection with hepatitis C virus.

It is very uncertain whether the intervention changes retransplantation after start of therapy ‐ interferon vs.control (very low certainty).

1 finding from 1 review

Alemtuzumab 24 mg vs interferon beta‐1a

Number of participants with serious adverse events · patients with relapsing‐remitting multiple sclerosis

Alemtuzumab 24 mg showed no clear difference in number of participants with serious adverse events compared with interferon beta 1a (moderate certainty).

1 finding from 1 review

Alemtuzumab 24 mg vs interferon beta‐1a

Number of participants with adverse events leading to study discontinuation · patients with relapsing‐remitting multiple sclerosis

It is very uncertain whether alemtuzumab 24 mg changes number of participants experiencing treatment discontinuation caused… compared with interferon beta 1a (very low certainty).

1 finding from 1 review

Alemtuzumab 12 mg vs interferon beta‐1a

Number of participants with serious adverse events · patients with relapsing‐remitting multiple sclerosis

Alemtuzumab 12 mg showed no clear difference in number of participants with serious adverse events compared with interferon beta 1a (moderate certainty).

1 finding from 1 review

Alemtuzumab 12 mg vs interferon beta‐1a

Number of participants with new T2‐hyperintense lesions on magnetic resonance imaging · patients with relapsing‐remitting multiple sclerosis

Alemtuzumab 12 mg may leads to lower number of participants with new T2‐hyperintense lesions on magnetic… compared with interferon beta 1a (low certainty).

1 finding from 1 review