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Evidence found and GRADE certainty

182 questions · 189 findings · 24 reviews · Pain, Palliative and Supportive Care

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No studies found 20 · 10.6%GRADE not reported 3 · 1.6%Very low 54 · 28.6%Low 62 · 32.8%Moderate 43 · 22.8%High 7 · 3.7%

Intervention not reported

Severe local reaction8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower severe local reaction8 (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐severe local reaction11 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower non‐severe local reaction11 (moderate certainty).

1 finding from 1 review

Intervention not reported

Fever15 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

It is very uncertain whether the intervention changes fever15 (very low certainty).

1 finding from 1 review

Intervention not reported

2c. Adequate immune response (seroprotection) against pertussis (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

2d. Adequate immune response (seroprotection) against Haemophilus influenzae type b disease (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to higher 2d. Adequate immune response (seroprotection) against Haemophilus… (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4b. Persistent inconsolable crying4 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

It is very uncertain whether the intervention changes 4b. Persistent inconsolable crying4 (very low certainty).

1 finding from 1 review

Intervention not reported

Severe local reaction8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower severe local reaction8 (moderate certainty).

1 finding from 1 review

Summary of findings: complete control of vomiting during the overall phase (MEC) when vs treatment with granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by moderately emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review