Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

598 questions · 645 findings · 40 reviews

No studies found 111 · 17.2%GRADE not reported 91 · 14.1%Very low 168 · 26%Low 146 · 22.6%Moderate 107 · 16.6%High 22 · 3.4%

Azathioprine or 6‐mercaptopurine vs placebo

Withdrawals due to adverse events · people with surgically‐induced remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Clinical relapse · people with surgically‐induced remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in clinical relapse compared with 5‐aminosalicylic acid (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Endoscopic relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes endoscopic relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Ustekinumab vs placebo

Failure to maintain remission · people with moderate to severe Crohn's disease in remission

Ustekinumab showed no clear difference in failure to maintain clinical remission compared with placebo (moderate certainty).

2 findings from 1 review

Ustekinumab vs placebo

Failure to maintain clinical response · people with moderate to severe Crohn's disease in remission

Ustekinumab probably leads to lower failure to maintain clinical response compared with placebo (moderate certainty).

2 findings from 1 review

Intervention not reported

OutcomesAnalysis 1.4 · Patients with active Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Failure to achieve clinical remission · Patients with active Crohn's disease

The intervention leads to lower failure to achieve clinical remission (high certainty).

1 finding from 1 review

Intervention not reported

Failure to achieve clinical response (70‐point response) · Patients with active Crohn's disease

The intervention leads to lower failure to achieve clinical response (70‐point response) (high certainty).

1 finding from 1 review