Findings

What do systematic reviews say?

162 questions · 163 findings · 18 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 47 · 28.8%GRADE not reported 0 · 0%Very low 28 · 17.2%Low 45 · 27.6%Moderate 35 · 21.5%High 8 · 4.9%

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Deaths · children with SCD who have been receiving prophylactic penicillin for at least two years

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 400 participants
Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 1.99 [0.18, 22.12]
1 study · 400 participants
Low