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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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440 to 550 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

440 to 550 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

SRP plus subgingival laser irradiation vs SRP

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

SRP plus subgingival laser irradiation showed no clear difference in volatile sulphur compounds (VSC) compared with SRP alone; GRADE not reported.

1 finding from 1 review

Acupressure at P6 point with sea band plus sedation vs Sham (dummy) acupressure with sedation

Presence or absence of gagging · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine + zinc acetate mouthwash vs Placebo mouthwash

Patient-reported OLT score · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 3 months
    Patient-reported OLT score: listed in the Summary of findings table but no data reported. No data were reported for patient-reported OLT score.
    0 studies
    No studies found

Laser (low-level laser) at P6 point vs sham control

Reduction in gagging (assessor-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled children

It is very uncertain whether laser (low-level laser) at P6 point changes reduction in gagging (assessor-reported) compared with control (sham/dummy laser) (very low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1000 to 1250 ppm F toothpaste leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).

1 finding from 1 review

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Composite resin for bonding brackets

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Resin-modified glass ionomer cement for bonding orthodontic brackets showed no clear difference in number of participants with new demineralised lesions (DLs) compared with light-cured composite resin for bonding brackets (low certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

It is very uncertain whether 2400 to 2800 ppm F toothpaste changes caries increment, tooth index D(M)FT compared with 1000 to 1250 ppm F toothpaste (very low certainty).

1 finding from 1 review

0.05% chlorhexidine + 0.05% cetylpyridinium chloride + 0.14% zinc lactate mouthrinse vs Placebo mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether halita mouthwash (chlorhexidine 0.05% + cetylpyridinium chloride… changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo mouthwash (very low certainty).

1 finding from 1 review

Active rinse (zinc acetate + chlorhexidine + sodium fluoride), with or without tongue scraping vs Negative control rinse, with or without tongue scraping

OLT and VSC scores · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Ademovski 2012 (4-arm cross-over trial) compared an active rinse (with/without tongue scraping) versus a negative control rinse (with/without tongue scraping); OLT and VSC. The authors did not report the correlation…
    1 study
    GRADE not reported

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Bleeding duration · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Acupressure at P6 point with device vs sham

Completion of dental treatment · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with device changes completion of dental procedure compared with sham (dummy) acupressure (very low certainty).

1 finding from 1 review

Oral irrigation plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Halita mouthrinse vs Perio-plus mouthrinse

Volatile sulphur compounds (VSC), gas chromatography · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Halita mouthrinse showed no clear difference in volatile sulphur compounds (VSC), portable gas chromatograph compared with perio-plus mouthrinse; GRADE not reported.

1 finding from 1 review

Lactobacillus brevis CD2 lozenges vs placebo control

OLT, VSC and breath print scores · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Marchetti 2015 (2-arm RCT) compared Lactobacillus brevis CD2 lozenges versus placebo lozenges (OLT, VSC and breath print). The study did not report any usable data and hence could not be included in the meta-analysis.
    1 study
    GRADE not reported

Acupressure at P6 point with device vs sham

Adverse effects · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Cetylpyridinium chloride mouthwash vs Placebo mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether cetylpyridinium chloride mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo mouthwash (very low certainty).

1 finding from 1 review