Findings

What do systematic reviews say?

2,545 questions · 2,661 findings · 317 reviews

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No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Intermittent oral vs oral calcitriol

Fall in PTH · patients with bone disease in children with chronic kidney disease

Intermittent oral showed no clear difference in fall in PTH compared with daily oral calcitriol (moderate certainty).

2 findings from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
RR 0.88 [0.65, 1.19]
1 study · 59 participants
Moderate
Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Moderate

Intermittent oral vs oral calcitriol

Kidney function · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Moderate

Intermittent oral vs oral calcitriol

Adverse events ‐ Calcium > 11.5 mg/dL · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Moderate

Intermittent oral vs oral calcitriol

Adverse events ‐ Phosphorus level > 7.5 mg/dL · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Vitamin D vs placebo/no treatment

PTH · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

Vitamin D vs placebo/no treatment

Number without 30% fall in PTH on two occasions · patients with bone disease in children with chronic kidney disease

Vitamin D preparations may leads to lower number without 30% fall in PTH on two occasions compared with placebo/no treatment (low certainty).

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
RR 0.6 [0.4, 0.89]
2 studies · 76 participants
Low

Vitamin D vs placebo/no treatment

Hypercalcaemia · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 103 participants
Low

Vitamin D vs placebo/no treatment

Change in calcium‐phosphorus product mg(2)/dL(2) · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 76 participants
Moderate

Calcitriol vs ergocalciferol

Height velocity equal to or greater than expected · patients with bone disease in children with chronic kidney disease

It is very uncertain whether calcitriol changes height velocity equal to or greater than expected compared with ergocalciferol (very low certainty).

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
RR 0.22 [0.03, 1.53]
1 study · 15 participants
Very low

Calcitriol vs ergocalciferol

PTH · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Calcitriol vs ergocalciferol

Hypercalcaemia · patients with bone disease in children with chronic kidney disease

It is very uncertain whether calcitriol changes hypercalcaemia compared with ergocalciferol (very low certainty).

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
RR 1.75 [0.68, 4.5]
1 study · 15 participants
Very low

Calcitriol vs ergocalciferol

Calcium mg/dL · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Calcitriol vs ergocalciferol

Phosphorus mmol/L · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Calcitriol vs ergocalciferol

ALP U/L · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Calcium carbonate vs aluminium hydroxide

Height SDS · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Calcium carbonate vs aluminium hydroxide

PTH · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Calcium carbonate vs aluminium hydroxide

ALP U/L · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Calcium carbonate vs aluminium hydroxide

Hypercalcaemia · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Summary of findings: Sevelamer vs calcium carbonate

PTH · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Summary of findings: Sevelamer vs calcium carbonate

ALP U/L · patients with bone disease in children with chronic kidney disease

1 finding from 1 review

Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low