Findings

What do systematic reviews say?

2,545 questions · 2,661 findings · 317 reviews

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No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Intervention not reported

Work absence · General practitioners/family doctors involved in the management of patients with other musculoskeletal conditions

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Quality of life · General practitioners/family doctors involved in the management of patients with other musculoskeletal conditions

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Economic outcomes Health service costs (including prescribing costs) Cost effectiveness · General practitioners/family doctors involved in the management of patients with other musculoskeletal conditions

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient outcomes Fragility fractures Hospitalisation · General practitioners/family doctors involved in the management of patients with osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Economic outcomes Health service costs (including prescribing costs) Cost effectiveness · General practitioners/family doctors involved in the management of patients with osteoporosis

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 272 participants
Low

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
Baseline and 6 months
no estimate extracted
1 study · 49 participants
GRADE not reported

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Flutamide 250 mg once to b.i.d. showed no clear difference in participant‐reported improvement of hirsutism 4‐point Likert scale compared with spironolactone 100 mg (low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 2 [0.88, 4.54]
1 study · 20 participants
Low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Proportion of participants who reported an adverse event · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Very low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Moderate

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Change in BMI ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs spironolactone 100 mg

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Low

Finasteride 5 mg vs spironolactone 100 mg

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs spironolactone 100 mg

Proportion of participants who reported an adverse event · women with hirsutism

Finasteride 5 mg showed no clear difference in proportion of participants who reported an adverse event compared with spironolactone 100 mg (moderate certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 0.2 [0.03, 1.41]
1 study · 20 participants
Moderate

Finasteride 5 mg vs spironolactone 100 mg

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Low

Finasteride 5 mg vs spironolactone 100 mg

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Low

Finasteride 5 mg vs spironolactone 100 mg

Change in BMI ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs spironolactone 100 mg

Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found