What do systematic reviews say?

Any glucocorticoid vs no glucocorticoids or placebo

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup ICSI compared with no glucocorticoids or placebo (very low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.08 [0.81, 1.42]
  6 studies · 992 participants
  Very low

Interventions for involving patients in decision‐making about their health care vs usual care

• Shared decision‐making interventions for people with mental health conditions 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Very low

Interventions for involving patients in decision‐making about their health care vs usual care

• Shared decision‐making interventions for people with mental health conditions 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 717 participants
  Low

Interventions for involving patients in decision‐making about their health care vs usual care

• Shared decision‐making interventions for people with mental health conditions 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 898 participants
  Low

Antioxidants vs placebo or no treatment

Antioxidants may leads to higher clinical pregnancy rate per couple randomised compared with placebo or no treatment (low certainty).

• Antioxidants for male subfertility 2022 · Cochrane Headline outcomes only
  OR 1.89 [1.45, 2.47]
  20 studies · 1706 participants
  Low

Intratympanic corticosteroids vs systemic corticosteroids

Intratympanic corticosteroids showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 701 participants
  Low

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Intratympanic plus systemic corticosteroids (combined therapy) showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids alone (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 435 participants
  Low

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

It is very uncertain whether intratympanic plus systemic corticosteroids (combined therapy) changes final hearing threshold determined by PTA A lower value represents… compared with systemic corticosteroids alone (very low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 194 participants
  Very low

Intratympanic corticosteroids vs no treatment or versus placebo

Intratympanic corticosteroids showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with no treatment or versus placebo (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 280 participants
  Low

Intratympanic corticosteroids vs no treatment or versus placebo

Intratympanic corticosteroids showed no clear difference in final hearing threshold determined by PTA (a lower value represents… compared with no treatment or versus placebo (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 203 participants
  Low

Intratympanic corticosteroids vs systemic corticosteroids

Intratympanic corticosteroids showed no clear difference in final hearing threshold determined by PTA (a lower value represents… compared with systemic corticosteroids (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 516 participants
  Low

Appetite stimulants vs placebo

• Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 42 participants
  Low
• Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Low

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

• Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 44 participants
  Very low

Habitat manipulation vs no intervention

It is very uncertain whether habitat manipulation changes malaria parasite prevalence compared with no intervention (very low certainty).

• Mosquito aquatic habitat modification and manipulation interventions to control malaria 2022 · Cochrane Headline outcomes only
  RR 0.01 [0, 0.16]
  2 participants
  Very low

Habitat manipulation with larviciding vs no intervention

It is very uncertain whether habitat manipulation with larviciding changes malaria parasite prevalence compared with no intervention (very low certainty).

• Mosquito aquatic habitat modification and manipulation interventions to control malaria 2022 · Cochrane Headline outcomes only
  OR 0.59 [0.42, 0.83]
  1 participants
  Very low

Habitat manipulation and modification with larviciding vs no intervention

Habitat manipulation and modification with larviciding showed no clear difference in malaria parasite prevalence compared with no intervention (moderate certainty).

• Mosquito aquatic habitat modification and manipulation interventions to control malaria 2022 · Cochrane Headline outcomes only
  OR 0.8 [0.41, 1.55]
  1 participants
  Moderate

Opioid antagonists vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Low

Mood stabilisers vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 71 participants
  Very low

Atypical antipsychotics vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 21 participants
  Very low

Opioid antagonists vs mood stabilisers

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low