Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,121 questions · 2,186 findings · 242 reviews

No studies found 493 · 22.6%GRADE not reported 158 · 7.2%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.7%High 97 · 4.4%

Gram‐negative and anaerobic coverage vs gram‐positive, gram‐negative, and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐negative and anaerobic coverage changes intra‐abdominal infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐positive and gram‐negative coverage vs gram‐negative and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐positive and gram‐negative coverage changes abdominal surgical site infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐positive and gram‐negative coverage vs gram‐negative and anaerobic coverage

All‐cause mortality · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐positive and gram‐negative coverage changes mortality compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐positive and gram‐negative coverage vs gram‐negative and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐positive and gram‐negative coverage changes intra‐abdominal infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐positive, gram‐negative, and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes abdominal surgical site infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐positive, gram‐negative, and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes intra‐abdominal infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Microbiological failure Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin probably leads to higher microbiological failure Men compared with doxycycline (moderate certainty).

1 finding from 1 review

Doxycycline vs quinolones

Microbiological failure Men and women Doxycycline 100 mg twice a day for 7 days vs ofloxacin 300 mg once a day for 7 days · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…
1 finding from 1 review

Doxycycline vs quinolones

Adverse events (Analysis 1.7) Participant's report · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Clinical failure Men Doxycycline 100 mg twice a day for 7 days vs ofloxacin 400 mg once a day for 7 days · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes clinical failure Men Doxycycline 100 mg twice a day for 7 days vs… compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Clinical failure Women Doxycycline 100 mg twice a day for 7 days vs ofloxacin 400 mg once a day for 7 days. · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes clinical failure Women Doxycycline 100 mg twice a day for 7 days vs… compared with quinolones (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Microbiological failure Women · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether azithromycin changes microbiological failure Women compared with doxycycline (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Adverse events Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin showed no clear difference in adverse events Men compared with doxycycline (low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Adverse events Men and women · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin probably leads to lower adverse events Men and women compared with doxycycline (moderate certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Clinical failure Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin showed no clear difference in clinical failure Men compared with doxycycline (low certainty).

1 finding from 1 review