Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · Oral Health

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Oral gabapentin vs placebo

Participants' assessment of global function (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) showed no clear difference in participants' assessment of global function (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral gabapentin vs placebo

Number of tender sites on muscles of mastication (palpation index) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) led to lower number of tender sites on muscles of mastication (palpation index) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral gabapentin vs placebo

Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) led to lower spontaneous pain in the TMJ (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Pain at rest (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in pain at rest (not improved) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral cyclobenzaprine (muscle relaxant) vs placebo

Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral cyclobenzaprine (muscle relaxant) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Limitation of movement · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral propranolol vs placebo

Adverse events ‐ treatment emergent · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Screening for domestic violence vs No screening

Proportion of victims of domestic violence detected by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Participants' assessment of improvement of pain in left TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in participants' assessment of improvement of pain in left TMJ (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of left masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of left masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Hypnosis vs No hypnosis (no hypnotic intervention)

Difference in post-operative anxiety between test and control groups · Children and adolescents (0 to 16 years) needing dental treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Difference in post-operative anxiety was a protocol-planned outcome but was not measured or reported by any included study (no post-operative anxiety scale was reported).
    Studies not reported
    No studies found

Piroxicam vs placebo

Number of participants with severe dysfunction (pain of TMD not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral piroxicam (NSAID) showed no clear difference in number of participants with severe dysfunction (pain of TMD not… compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Pain on daily activity (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in pain on daily activity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral cyclobenzaprine (muscle relaxant) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral celecoxib (COX-2 inhibitor) vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral celecoxib (COX-2 inhibitor) showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Maximum pain while on medication (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in maximum pain while on medication (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review