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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Outcome not reported · People with Von Willebrand disease undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture at P6 point vs sham

Successful completion of dental procedure · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupuncture at P6 point changes successful completion of dental procedure compared with sham acupuncture (very low certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 1700 to 2200 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1700 to 2200 ppm F toothpaste (low certainty).

1 finding from 1 review

0.6% eucalyptus chewing gum vs Placebo chewing gum

Patient-reported OLT score · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 4 weeks
    Patient-reported OLT score: listed in the Summary of findings table but no data reported. No data were reported for patient-reported OLT score.
    0 studies
    No studies found

Acupressure at P6 point with sea band plus sedation vs Sham (dummy) acupressure with sedation

Adverse effects · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes plaque compared with interdental brushing plus toothbrushing (very low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1450 to 1500 ppm F toothpaste (moderate certainty).

1 finding from 1 review

Chlorine dioxide mouthrinse (with tongue scraping) vs Chlorhexidine mouthwash (with tongue scraping)

VSC: methyl mercaptan · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Chlorine dioxide mouthrinse (with tongue scraping) showed no clear difference in VSC: methyl mercaptan compared with chlorhexidine mouthwash (with tongue scraping); GRADE not reported.

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 1450 to 1500 ppm F toothpaste (low certainty).

1 finding from 1 review

Sodium bicarbonate toothpaste vs Control toothpaste (without sodium bicarbonate)

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Sodium bicarbonate toothpaste showed no clear difference in volatile sulphur compounds (VSC) compared with control toothpaste (without sodium bicarbonate); GRADE not reported.

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

Scaling and root planing (SRP) plus glycine powder air polishing vs Scaling/root planing alone

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Scaling and root planing (SRP) plus glycine powder air polishing showed no clear difference in volatile sulphur compounds (VSC), halimeter compared with scaling and root planing (SRP) alone; GRADE not reported.

1 finding from 1 review

Essential oil mouthwash vs Placebo mouthwash

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Essential oil mouthwash showed no clear difference in volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

2 findings from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    2 weeks
    MD -5.13 [-32.94, 22.68]
    1 study · 45 participants
    GRADE not reported
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Garcia 2014 (2-arm RCT) compared essential oil mouthwash versus placebo mouthwash (VSC by halimeter). We could not include the results in the meta-analysis because of the missing SD and P value.
    1 study
    GRADE not reported

Cetylpyridinium chloride mouthwash vs Placebo mouthwash

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Cetylpyridinium chloride mouthwash led to lower volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

1 finding from 1 review

Hinokitiol gel vs Placebo gel

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether hinokitiol gel changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo gel (very low certainty).

1 finding from 1 review

1000 mg champignon extract vs placebo

Patient's family member-reported VAS score (scale 0 to 100) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

1000 mg champignon extract showed no clear difference in patient's family member-reported VAS score (scale 0 to 100) compared with placebo; GRADE not reported.

1 finding from 1 review