What do systematic reviews say?

Silodosin vs placebo

Silodosin showed no clear difference in treatment withdrawal due to any reason compared with placebo (low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 1.08 [0.7, 1.66]
  3 studies · 1703 participants
  Low

Silodosin vs placebo

It is very uncertain whether silodosin changes cardiovascular adverse events compared with placebo (very low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 1.28 [0.67, 2.45]
  4 studies · 1967 participants
  Very low

Silodosin vs placebo

Silodosin probably leads to higher sexual adverse events compared with placebo (moderate certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 26.07 [12.36, 54.97]
  4 studies · 1967 participants
  Moderate

Silodosin vs tamsulosin

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 1708 participants
  Low

Silodosin vs tamsulosin

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 1707 participants
  Low

Silodosin vs tamsulosin

It is very uncertain whether silodosin changes treatment withdrawal due to any reason compared with tamsulosin (very low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 1.02 [0.62, 1.69]
  10 studies · 1573 participants
  Very low

Silodosin vs tamsulosin

Silodosin showed no clear difference in cardiovascular adverse events compared with tamsulosin (low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 0.77 [0.53, 1.12]
  11 studies · 1955 participants
  Low

Double vs single‐injection technique

Double leads to lower primary anaesthesia failure (incomplete sensory block) compared with single‐injection technique (high certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.55 [0.34, 0.89]
  9 studies · 527 participants
  High

Multiple vs single‐injection technique

Multiple showed no clear difference in secondary analgesia failure ‐ tourniquet pain compared with single‐injection technique (high certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.97 [0.3, 3.11]
  4 studies · 379 participants
  High

Multiple vs single‐injection technique

Multiple showed no clear difference in complete failure of block1 compared with single‐injection technique (moderate certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.31 [0.03, 2.71]
  7 studies · 484 participants
  Moderate

Multiple vs single‐injection technique

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 206 participants
  Low

Multiple vs single‐injection technique

Multiple showed no clear difference in intravascular injection compared with single‐injection technique (moderate certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 1.35 [0.2, 9.06]
  4 studies · 352 participants
  Moderate

Multiple vs single‐injection technique

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 244 participants
  Low

Multiple vs double‐injection technique

Multiple leads to lower primary anaesthesia failure compared with double‐injection technique (high certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.27 [0.19, 0.39]
  12 studies · 966 participants
  High

Multiple vs double‐injection technique

Multiple showed no clear difference in secondary analgesia failure ‐ intraoperative sedation required compared with double‐injection technique (high certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.75 [0.55, 1.03]
  7 studies · 716 participants
  High

Multiple vs double‐injection technique

Multiple leads to lower secondary analgesia failure ‐ tourniquet pain compared with double‐injection technique (high certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.53 [0.33, 0.84]
  7 studies · 719 participants
  High

Multiple vs double‐injection technique

Multiple showed no clear difference in complete failure of block1 compared with double‐injection technique (low certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.24 [0.04, 1.41]
  9 studies · 630 participants
  Low

Multiple vs double‐injection technique

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 524 participants
  Moderate

Double vs single‐injection technique

Double showed no clear difference in secondary analgesia failure ‐ intraoperative sedation required compared with single‐injection technique (moderate certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.64 [0.31, 1.31]
  2 studies · 129 participants
  Moderate

Multiple vs double‐injection technique

Multiple showed no clear difference in intravascular injection compared with double‐injection technique (moderate certainty).

• Single, double or multiple‐injection techniques for non‐ultrasound guided axillary brachial plexus block in adults… 2016 · Cochrane Headline outcomes only
  RR 0.69 [0.32, 1.49]
  7 studies · 676 participants
  Moderate